Brazilian version of the European Cross-Cultural Neuropsychological Test Battery (CNTB-BR): diagnostic accuracy across schooling levels

Objective: To translate, establish the diagnostic accuracy, and standardize the Brazilian Portuguese version of the European Cross-Cultural Neuropsychological Test Battery (CNTB) considering schooling level. Methods: We first completed an English-Brazilian Portuguese translation and back-translation of the CNTB. A total of 135 subjects aged over 60 years - 65 cognitively healthy (mean 72.83, SD = 7.71; mean education 9.42, SD = 7.69; illiterate = 25.8%) and 70 with Alzheimer's disease (AD) (mean 78.87, SD = 7.09; mean education 7.62, SD = 5.13; illiterate = 10%) - completed an interview and were screened for depression. The receiver operating characteristic (ROC) analysis was used to verify the accuracy of each CNTB test to separate AD from healthy controls in participants with low levels of education (≤ 4 years of schooling) and high levels of education (≥ 8 years of schooling). The optimal cutoff score was determined for each test. Results: The Recall of Pictures Test (RPT)-delayed recall and the Enhanced Cued Recall (ECR) had the highest power to separate AD from controls. The tests with the least impact from schooling were the Rowland Universal Dementia Assessment Scale (RUDAS), supermarket fluency, RPT naming, delayed recall and recognition, and ECR. Conclusions: The Brazilian Portuguese version of the CNTB was well comprehended by the participants. The cognitive tests that best discriminated patients with AD from controls in lower and higher schooling participants were RPT delayed recall and ECR, both of which evaluate memory.

Association among 2-min step test, functional level and diagnosis of dementia / Associação entre o nível de capacidade aeróbica e diagnóstico de demência

ABSTRACT: Aerobic capacity declines significantly throughout life, beginning at the age of 30 years and accelerating from 60 years, where a decline of 17% per decade is expected thereafter. Objective: To investigate the association between aerobic capacity and a diagnosis of mild cognitive impairment (MCI), mild AD or moderate AD in older adults, considering the risk classification of functional loss of the Step test. Methods: In this cross-sectional study, 93 patients (age >60 years) were evaluated (Healthy=36; MCI=18, AD=39). The step test was used to assess aerobic capacity, while overall cognitive status was measured using the MMSE. The groups were divided according to the risk classifications of functional loss into below or above the standard cut-off point for aerobic capacity. Results: Subjects in the functional loss risk group were approximately ten to fourteen times more likely to be diagnosed with mild (OR:10.7; p=0.001) or moderate (OR.=14.7; p=0.002) AD than their fitter counterparts. Low aerobic fitness was also associated with the MCI condition (OR=4.5; p=0.05), but only after controlling for educational level, age and sex. In the overall sample (N=93), there was an association between aerobic capacity and MMSE performance (R2=0.35; p<0.001) after controlling for confounding variables. Conclusion: low aerobic capacity was associated with cognitive decline, and older adults at risk of functional loss on the STEP test had greater chance of being diagnosed with MCI or AD after controlling for age, sex and education.

RESUMO: A capacidade aeróbica diminui significativamente ao longo da vida, começando com a idade de 30 anos e acelerando a partir dos 60 anos, onde se prevê um declínio de 17% por década. Objetivo: Investigar a associação entre a capacidade aeróbica medida e o risco de desenvolvimento de comprometimento cognitivo leve (CCL), DA leve e moderado em idosos, considerando as classificações de risco de perda funcional para o teste do STEP. Métodos: Nesse estudo de corte-transversal, foram avaliados 93 idosos (>60 anos) (saudáveis=36; CCL=18, DA=39). Para acessar a capacidade aeróbica foi utilizado o teste de STEP e o estado cognitivo global foi medido através do MEEM. Os grupos foram divididos em relação às classificações de risco de perda funcional em abaixo ou acima do ponto de corte padronizado para idosos. Resultados: Idosos incluídos no grupo de risco de perda funcional tinham aproximadamente dez a catorze vezes mais chances de serem diagnosticados com DA leve (O.R:10.7; p=0.001) e moderado (O.R.=14.7; p=0.002), do que os seus pares mais bem condicionados. Menores níveis de capacidade aeróbica também foram associados com o diagnostico de CCL (O.R=4.5; p=0.05), entretanto apenas após controle por idade, escolaridade e sexo. Na amostra total (N=93) houve uma associação entre a capacidade aeróbica e o MEEM (R2=0.35; p<0.001) depois de controlado pelas variáveis confundidoras. Conclusão: Idosos que se encontram dentro da classificação de risco de perda funcional medida através do teste de STEP possuem maiores chances de desenvolverem CCL, Alzheimer leve e moderado mesmo após controle por idade, sexo e escolaridade.

The effects of regular physical activity on anxiety symptoms in healthy older adults: a systematic review

Objective: Anxiety symptoms are common in older adults with or without anxiety disorders. Pharmacological options may be limited for these patients. Alternative treatments, such as physical activity (PA), are often indicated, although few trials have evaluated their efficacy. The aim of this review was to evaluate the efficacy of regular PA on improving anxiety symptoms in older adults without anxiety disorders. Potential neuroendocrine, inflammatory, and oxidative mechanisms, as well as cognitive factors to explain these effects are also discussed. Methods: A systematic literature review was performed to identify randomized controlled trials, cross-sectional, cohort, and case-control studies, as well as case series including healthy previously sedentary older adults. We searched the PubMed and Web of Science databases for articles published in English, with no set time limits. Results: Eight studies evaluating the effect of PA on anxiety symptoms in healthy older adults were included in this review. In all studies, regular and supervised PA was directly related to decreased anxiety symptoms in older individuals. Conclusion: Regular PA may be effective for improving anxiety symptoms in older adults. More studies are needed to identify the ideal PA modality, frequency, duration, and intensity for optimizing the positive effects of exercise on anxiety in this population.